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Actor James McCaffrey attends the premiere of “Meskada” during the 2010 Tribeca Film Festival at the Village East Cinema on April 22, 2010, in New York City.

James McCaffrey, the “Rescue Me” star and actor who brought vigilante police detective Max Payne to life in the eponymous video game, has died. He was 65.

McCaffrey died Sunday at home in Larchmont, New York, after being diagnosed with multiple myeloma — a cancer that forms in white blood cells — his talent agent David Elliott confirmed Monday to The Times.