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2007, Acta Dermato-Venereologica
Ultrastructural Pathology
Detection of Silver Sulfide Deposits in the Skin of Patients with Argyria After Long-term Use of Silver-containing Drugs2007 •
Acta Clinica Belgica
Long Term Use of Silver Containing Nose-Drops Resulting in Systemic Argyria2005 •
The Journal of the American Osteopathic Association
Argyria: Report of a case associated with abnormal electroencephalographic and brain scan findings1987 •
Indian Journal of Dermatology, Venereology, and Leprology
Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: A case series and review of the literature2013 •
2000 •
One of the most effective anti-microbial therapies available to wholistic health practitioners today is Mild Silver Protein (MSP). Silver use as an antibiotic is not new. It has a long history and it has undergone resurgence of late. Even if you are not familiar with colloidal silver, you can be sure some of your patients are already using it. This article is about information you need to be aware of as their doctor. All silver products are not created equal and its effectiveness varies considerably. Unfortunately, there is a lot of hype that has gone into the marketing of silver products. They include statements like: No one knows why silver is so lethal to pathogenic organisms. "No known pathogenic virus or bacterium has been able to develop immunity to silver. Silver is not toxic to higher life forms and specifically in our case, humans. This misinformation may hurt consumers and cause the removal of what is presently a very promising and effective OTC remedy (Gulbranson, et. al., 2000). We have a good idea why silver as well as several other metals kill or inhibit microorganisms. These biocides enter the cell and in anionic or cationic (in silver's case) manner bind and disrupt cellular metabolic machinery and structure. In order to develop a resistance to these heavy metal biocides, bacteria carry out chemical transformations of heavy metals like silver. They occasionally develop, usually determined by extrachromosomal DNA (or plasmids), modification of normal metabolic processes like oxidation, reduction, methylation and demethylation to confer resistance. Silver sensitivity is caused by a cell's affinity to the binding of Ag+ more effectively than Cl-. In one instance, silver resistance is due to a lowered affinity of the cells for Ag+ that can be complexed with extracellular halides, thiols, or organic compounds. (Silver, Misra 1984) In another instance, silver resistance was felt to be to formation of silver-sulfide complexes. (Slawson, et. al., 1994) In still other instances, extrusion of the toxic ion from the bacterial cytoplasm takes place (Cervantes, Silver, 1996) by cellular pumps (Rosen, 1999) or a periplasmic silver binding protein is used (Gupta, et. al., 1999). Chronic exposure of microorganisms to silver helps facilitate resistance to silver as well as other antibiotics (Russel 1997). There is a relationship between release of silver from mercury-silver amalgams typically used in dentistry and the selective development of antibiotic resistance (Roberts 1998). On the other hand, it has been observed that the ability to develop silver resistance significantly reduces the organism's ability to act as pathogen. Silver should not be considered totally 'harmless' to higher life forms. Silver may permanently discolor skin. This is a condition called 'Agyria'. Agyria is noted as a 'permanent' ashen-gray discoloration of the skin, internal organs and conjunctiva. It is, however, considered a benign condition (Aaseth, et. al., 1981). Silver's usage in burn treatment, prothestetic implants and use in
Journal of the American Academy of Dermatology
Scar-localized argyria secondary to silver sulfadiazine cream2003 •
Silver is used widely in wound dressings and medical devices as a broad-spectrum antibiotic. Metallic silver and most inorganic silver compounds ionise in moisture, body fluids, and secretions to release biologically active Ag+. The ion is absorbed into the systemic circulation from the diet and drinking water, by inhalation and through intraparenteral administration. Percutaneous absorption of Ag+ through intact or damaged skin is low. Ag+ binds strongly to metallothionein, albumins, and macroglobulins and is metabolised to all tissues other than the brain and the central nervous system. Silver sulphide or silver selenide precipitates, bound lysosomally in soft tissues, are inert and not associated with an irreversible toxic change. Argyria and argyrosis are the principle effects associated with heavy deposition of insoluble silver precipitates in the dermis and cornea/conjunctiva. Whilst these changes may be profoundly disfiguring and persistent, they are not associated with pathological damage in any tissue. The present paper discusses the mechanisms of absorption and metabolism of silver in the human body, presumed mechanisms of argyria and argyrosis, and the elimination of silver-protein complexes in the bile and urine. Minimum blood silver levels consistent with early signs of argyria or argyrosis are not known. Silver allergy does occur but the extent of the problem is not known. Reference values for silver exposure are discussed.
2013 •
Clinical Cancer Research
Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency2006 •
Clinical Infectious Diseases
Guideline Recommendations: Optimal Timing of Publication and Resulting Rate of Adoption2015 •
Biomedical Journal of Scientific & Technical Research
Management of Outbreak of Salmonellosis in a Pig Farm Revealed Human Source of Infection in Cameroon1997 •
2015 •
arXiv: Dynamical Systems
An Asymptotic Analysis of Queues with Delayed Information and Time Varying Arrival Rates2017 •
Culture, health & sexuality
Playground love: sex work, pleasure, and self-affirmation in the urban nightlife of Indonesian waria2018 •
Laser Applications in Microelectronic and Optoelectronic Manufacturing VI
Time-resolved study of femtosecond microfabrication in silica glass2001 •
Osteoarthritis and Cartilage
026 Resorptive Bone Remodeling is a Prominent Feature of Bone Marrow Lesions Detected by Magnetic Resonance Imaging (Mri) in Osteoarthritis2010 •
2012 •
2019 •
Thyroid : official journal of the American Thyroid Association
Doxorubicin-Loaded Nanobubbles Combined with Extracorporeal Shock Waves: Basis for a New Drug Delivery Tool in Anaplastic Thyroid Cancer2016 •
2023 •
Cell J. 25(10): 688-695
Role of The circ-HIPK3, circ-PVT1, miR-25, and miR-149 in Response of Breast Cancer Cells to Ionizing Radiation2023 •
BMC Complementary and Alternative Medicine
Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain2012 •
Journal of Industrial and Engineering Chemistry
Temperature and alkaline hydroxide treatment effects on hydrogen sorption characteristics of multi-walled carbon nanotube–graphite mixture2009 •
Cuadernos de filología inglesa
A view of 14th-century contemplation: Walter Hilton'sRevista de la construcción
Minimum geotechnical requirements for traditional and singular bridges foundations design: Chacao Suspension Bridge2017 •
Promoting Self-Change from Problem Substance Use
Self-change from alcohol and drug abuse: often cited classics2001 •
Clinical Rheumatology
Reproducibility of a low back pain questionnaire in Tunisian adolescents2006 •